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Predictive markers for mammoplasty and a comparison of side effect profiles in transwomen taking various hormonal regimens.
"With regard to the use of antiandrogens, the major side effect was an increased rate of depression compared with that seen in those treated with GnRH analogs (7.6 vs. 2.2%, P 0.029) (see Table 4). It should be remembered that this is in the context of a background rate of depression reported in 35.6 and 34.1% of clients, respectively, before treatment. Of the antiandrogens studied, only cyproterone acetate was significantly associated with depression(8.3%, P 0.05) (see Table 4)."
"Cyproterone acetate use is statistically more likely to cause depression than the other antiandrogen types used in this study. These results are consistent with previous studies using cyproterone acetate to treat hirsutism (11–13). It is, however, the first time this has been reported in transwomen. The incidence of depression was much lower in those using GnRH analogs, which is consistent with the findings of Dittrich et al. in 2005 (14), who found that depression was not a significant problem in transwomen treated with GnRH analogs."
"Because cyproterone acetate was associated with an increased incidence of depression compared with GnRH analogs, it could be argued that GnRH analogs are better for testosterone reduction."
European Journal of Endocrinology (2011) 164 635–642
A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones
"Depressive mood changes have been reported in cyproterone acetate use but these are usually transient occurring during the first 6 months of use."
Posté le: 06/02/2014 19:21:58 Sujet du message: Publicité